Description

3-(6,7-Dihydro-1-Methyl-3-Propyl-7-Thioxo-1H-Pyrazolo[4,3-D]Pyrimidin-5-Yl)-4-Ethoxy-Benzenesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in programs targeting specific enzyme inhibition. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of PDE5 inhibitors and related therapeutic compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in multi-step synthetic routes for target API molecules.
• Biochemical Research: Employed as a tool compound in enzymatic assays and pharmacological studies.
• Contract Manufacturing: Supplied to CDMOs for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	3-(6,7-Dihydro-1-Methyl-3-Propy-7-Thioxo-1H-Pyrazolo[4,3-D]Pyrimidin-5-Yl)-4-Ethoxy-Benzenesulfonyl Chloride
CAS No.	479074-07-2
Molecular Formula	C17H19ClN4O3S2
Molecular Weight	426.94 g/mol
Synonyms	4-Ethoxy-3-(1-methyl-3-propyl-7-thioxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride; 3-(1-Methyl-3-propyl-7-thioxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxybenzenesulfonyl chloride; 479074-07-2; Tadalafil sulfonyl chloride intermediate; PDE5 inhibitor intermediate; Pyrazolopyrimidine sulfonyl chloride.
EINECS	Contact for details

Quality Control

Our 3-(6,7-Dihydro-1-Methyl-3-Propyl-7-Thioxo-1H-Pyrazolo[4,3-D]Pyrimidin-5-Yl)-4-Ethoxy-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.