Description

Fmoc-(R)-3-Amino-3-(4-Fluoro-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This chiral building block is critical for introducing the unique (R)-3-amino-3-(4-fluorophenyl)propionic acid moiety into complex molecules, enabling the development of novel bioactive compounds. It is an essential reagent for medicinal chemists and researchers in pharmaceutical R&D, biotechnology, and fine chemical synthesis who require reliable, high-quality intermediates for drug discovery programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing fluorinated aromatic side chains.
• Pharmaceutical Intermediate: Serves as a critical chiral building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptidomimetic Design: Used to create peptide analogs and mimetics with enhanced stability, bioavailability, and receptor binding affinity.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Bioconjugation: Facilitates the site-specific modification of peptides, proteins, and other biomolecules for diagnostic and therapeutic applications.
• Academic & Industrial Research: A valuable tool for studying structure-activity relationships (SAR) and for the chemical synthesis of novel fluorinated compounds.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(4-Fluoro-Phenyl)-Propionic Acid
CAS No.	479064-95-4
Molecular Formula	C24H20FNO4
Molecular Weight	405.42 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(4-fluorophenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(4-fluorophenyl)-(R)-propionic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic Acid; Fmoc-3-Amino-3-(4-fluoro-phenyl)-propionic acid-(R); Fmoc-(R)-A-(4-Fluorophenyl)-β-alanine; N-α-Fmoc-(R)-3-(4-Fluorophenyl)-β-alanine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-fluorophenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(4-Fluoro-Phenyl)-Propionic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and development applications. All products undergo rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.