Description

2-Methoxy-5-(Trifluoromethoxy)Benzyl Bromide is a high-value, multi-functional benzyl bromide derivative used as a critical building block in advanced organic synthesis. Its unique structure, featuring both methoxy and trifluoromethoxy substituents, makes it an essential reagent for introducing specific aromatic motifs into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used to construct advanced herbicide and pesticide molecules, leveraging the stability and lipophilicity imparted by the trifluoromethoxy group.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating specialized aromatic cores in electronic and display materials.
• Cross-Coupling Reactions: Acts as an efficient electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Group Transformation: The reactive benzyl bromide moiety allows for conversion to various other functional groups, such as alcohols, amines, and thioethers.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and affinity tags due to its selective reactivity.

Basic Information

Product Name	2-Methoxy-5-(Trifluoromethoxy)Benzyl Bromide
CAS No.	478484-53-6
Molecular Formula	C9H8BrF3O2
Molecular Weight	285.06 g/mol
Synonyms	1-(Bromomethyl)-2-methoxy-5-(trifluoromethoxy)benzene; α-Bromo-2-methoxy-α,α,α-trifluoro-p-cresol Methyl Ether; 2-Methoxy-5-(trifluoromethoxy)benzyl bromide; 5-(Trifluoromethoxy)-2-methoxybenzyl bromide; (2-Methoxy-5-(trifluoromethoxy)phenyl)methyl bromide; 1-Bromo-2-methoxy-4-(trifluoromethoxy)methylbenzene; 2-Methoxy-α-(trifluoromethoxy)benzyl bromide
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(Trifluoromethoxy)Benzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.