Description

Fmoc-D-Phe(2-I)-Oh CAS NO 478183-65-2 is a protected, non-natural amino acid derivative featuring an iodine substituent on the phenylalanine aromatic ring. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise introduction of halogenated aromatic side chains to modulate peptide properties. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-based therapeutics, diagnostic probes, and materials science applications where structural modification is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides and small proteins.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide drugs, including hormone analogs and antimicrobial peptides.
• Chemical Biology Probes: Incorporation into peptides for photoaffinity labeling, bioconjugation, or as a handle for further functionalization via halogen chemistry.
• Structure-Activity Relationship (SAR) Studies: Enables the study of how halogenation affects peptide-receptor binding, stability, and activity.
• Material Science: Serves as a building block for peptide-based polymers and biomaterials with tailored properties.
• Academic & Industrial Research: A valuable reagent for exploring new synthetic methodologies and peptide architectures in R&D laboratories.

Basic Information

Product Name	Fmoc-D-Phe(2-I)-Oh
CAS No.	478183-65-2
Molecular Formula	C24H20INO4
Molecular Weight	521.33 g/mol
Synonyms	Fmoc-2-iodo-D-phenylalanine; N-(9-Fluorenylmethoxycarbonyl)-2-iodo-D-phenylalanine; Fmoc-D-2-Iodophenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-iodophenyl)propanoic acid; Fmoc-D-Phe(2I)-OH; N-α-Fmoc-2-iodo-D-phenylalanine; Fmoc-2-I-D-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Phe(2-I)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee reproducible performance in your sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.