Description

(R)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(3-Chloro-4-Hydroxyphenyl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a protected amine group. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, where its specific stereochemistry and functional groups enable precise molecular design. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing targeted therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid building block to introduce the (R)-3-(3-chloro-4-hydroxyphenyl)alanine moiety.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescent or affinity probes due to the reactive carboxylic acid and protected amine, useful in biochemical assays.
• Chemical Biology Research: Employed in studying enzyme-substrate interactions, receptor binding, and structure-activity relationships (SAR) in medicinal chemistry programs.
• Process Chemistry: Used in scaling up synthetic routes for candidate drugs during preclinical and early clinical development stages.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Product Name	(R)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(3-Chloro-4-Hydroxyphenyl)Propanoic Acid
CAS No.	478183-59-4
Molecular Formula	C24H20ClNO5
Molecular Weight	437.87 g/mol
Synonyms	Fmoc-(R)-3-(3-Chloro-4-hydroxyphenyl)alanine; (R)-Fmoc-3-(3-Chloro-4-hydroxy-Phe)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-chloro-4-hydroxyphenyl)propanoic acid; Fmoc-(R)-3-Cl-4-OH-Phe-OH; N-α-Fmoc-O-(3-chloro-4-hydroxybenzyl)-D-serine (cyclic form related); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-chloro-4-hydroxyphenyl)-D-alanine; D-Fmoc-3-chloro-4-hydroxy-phenylalanine; Fmoc-D-3-Cl-4-OH-Phe
EINECS	Contact for details

Quality Control

Our (R)-2-(((9H-Fluoren-9-Yl)Methoxy)Carbonylamino)-3-(3-Chloro-4-Hydroxyphenyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.