Description

4-(3-[(2,4-Dichlorobenzyl)Oxy]Phenyl)-2-Pyrimidinamine is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrimidinamine core and dichlorobenzyloxy substituent. This compound is of significant value in medicinal chemistry research and development, serving as a critical building block for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new drug candidates, particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Kinase Inhibitor Development: Serves as a starting material or intermediate in the research of protein kinase inhibitors, given the pyrimidinamine structure's relevance to this drug class.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to create more complex molecules for biological evaluation.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Item	Detail
Product Name	4-(3-[(2,4-Dichlorobenzyl)Oxy]Phenyl)-2-Pyrimidinamine
CAS No.	478046-35-4
Molecular Formula	C17H13Cl2N3O
Molecular Weight	346.21 g/mol
Synonyms	4-[3-[(2,4-Dichlorophenyl)methoxy]phenyl]pyrimidin-2-amine; 2-Amino-4-[3-[(2,4-dichlorobenzyl)oxy]phenyl]pyrimidine; 4-(3-((2,4-Dichlorobenzyl)oxy)phenyl)pyrimidin-2-amine; UNII-9V8I3B2W9S; 9V8I3B2W9S; BDBM50111657; AKOS025310584; ZINC000257630509
EINECS	Contact for details

Quality Control

Every batch of 4-(3-[(2,4-Dichlorobenzyl)Oxy]Phenyl)-2-Pyrimidinamine is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with specifications typically meeting or exceeding 97% purity (HPLC). A Certificate of Analysis (COA) detailing batch-specific results for assay, related substances, and residual solvents is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.