Description

Pyrimidine, 4-Chloro-5-Methoxy-2-[3-(Trifluoromethyl)Phenyl]- is a high-value, multi-functional heterocyclic building block characterized by its pyrimidine core substituted with chloro, methoxy, and a trifluoromethylphenyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrimidine scaffold.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials, ligands for catalysis, and other functionalized aromatic systems.

Basic Information

Product Name	Pyrimidine, 4-Chloro-5-Methoxy-2-[3-(Trifluoromethyl)Phenyl]-
CAS No.	478030-28-3
Molecular Formula	C12H8ClF3N2O
Molecular Weight	288.65 g/mol
Synonyms	4-Chloro-5-methoxy-2-[3-(trifluoromethyl)phenyl]pyrimidine; 2-(3-(Trifluoromethyl)phenyl)-4-chloro-5-methoxypyrimidine; 4-Chloro-5-methoxy-2-(3-trifluoromethylphenyl)pyrimidine; 478030-28-3; 4-Chloro-5-methoxy-2-(α,α,α-trifluoro-m-tolyl)pyrimidine
EINECS	Contact for details

Quality Control

Our Pyrimidine, 4-Chloro-5-Methoxy-2-[3-(Trifluoromethyl)Phenyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical and agrochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.