Description

4-[1,1'-Biphenyl]-4-Yl-2-(3-Fluoro-4-Iodophenyl)Pyrimidine is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of targeted therapies. Its specific molecular architecture makes it a critical building block for probing new biological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the research and synthesis of potential drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a potential electron-transport or host material in the development of advanced OLED devices due to its conjugated biphenyl-pyrimidine system.
• Ligand in Catalysis: Can be utilized to develop novel ligands for transition metal catalysts used in cross-coupling and other synthetic transformations.
• Agrochemical Research: Investigated as an intermediate for developing new generation herbicides or fungicides with specific modes of action.
• Academic & Industrial R&D: Employed in universities and corporate R&D centers for fundamental research in organic synthesis and material science.

Basic Information

Product Name	4-[1,1'-Biphenyl]-4-Yl-2-(3-Fluoro-4-Iodophenyl)Pyrimidine
CAS No.	477870-86-3
Molecular Formula	C22H14FIN2
Molecular Weight	452.26 g/mol
Synonyms	2-(3-Fluoro-4-iodophenyl)-4-(4-phenylphenyl)pyrimidine; 4-Biphenyl-4-yl-2-(3-fluoro-4-iodophenyl)pyrimidine; [1,1'-Biphenyl]-4-yl(2-(3-fluoro-4-iodophenyl)pyrimidin-4-yl)methanone (tautomer consideration); 4-(4-Phenylphenyl)-2-(3-fluoro-4-iodophenyl)pyrimidine; CAS 477870-86-3
EINECS	Contact for details

Quality Control

Our production of 4-[1,1'-Biphenyl]-4-Yl-2-(3-Fluoro-4-Iodophenyl)Pyrimidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from prolonged exposure. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.