Description

4-Chlorophenyl [6-Morpholino-2-(2-Pyridinyl)-4-Pyrimidinyl]Methyl Sulfide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel, small-molecule therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and inflammatory disease research.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and optimizing compounds that modulate specific kinase activity, a major target class in modern drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities and improve pharmacological profiles.
• Biochemical Tool Compound: May be employed in vitro as a probe to study biological pathways and enzyme functions in academic and industrial R&D settings.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds for client projects.

Basic Information

Product Name	4-Chlorophenyl [6-Morpholino-2-(2-Pyridinyl)-4-Pyrimidinyl]Methyl Sulfide
CAS No.	477866-88-9
Molecular Formula	C20H19ClN4OS
Molecular Weight	398.91 g/mol
Synonyms	4-Chloro-phenyl-[6-morpholin-4-yl-2-(pyridin-2-yl)pyrimidin-4-yl]methyl sulfide; 2-(4-((4-Chlorophenyl)thiomethyl)-6-morpholinopyrimidin-2-yl)pyridine; (4-Chlorophenyl)[6-(4-morpholinyl)-2-(2-pyridinyl)-4-pyrimidinyl]methyl sulfide; 4-((4-Chlorophenylthio)methyl)-6-morpholino-2-(pyridin-2-yl)pyrimidine; CAS 477866-88-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, NMR, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.