Description

4-(4-Methylphenyl)-6-(4-Methylpiperazino)-2-Phenyl-5-Pyrimidinecarbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its complex pyrimidinecarbonitrile core structure. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, especially within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities (NCEs).
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex heterocyclic compounds due to its reactive nitrile and substituted pyrimidine functionalities.
• Biochemical Tool Compound: May be utilized in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Fine Chemical Production: Integral in the custom synthesis of high-value, low-volume specialty chemicals for advanced material science applications.

Basic Information

Product Name	4-(4-Methylphenyl)-6-(4-Methylpiperazino)-2-Phenyl-5-Pyrimidinecarbonitrile
CAS No.	477853-92-2
Molecular Formula	C23H23N5
Molecular Weight	369.47 g/mol
Synonyms	5-Cyano-4-(p-tolyl)-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine; 2-Phenyl-4-(4-methylphenyl)-6-(4-methylpiperazino)-5-pyrimidinecarbonitrile; 4-(4-Methylphenyl)-6-(4-methyl-1-piperazinyl)-2-phenyl-5-pyrimidinecarbonitrile; 4-(p-Tolyl)-6-(4-methylpiperazin-1-yl)-2-phenylpyrimidine-5-carbonitrile; 477853-92-2; UNII-9V6T6A7F4P
EINECS	Contact for details

Quality Control

Our 4-(4-Methylphenyl)-6-(4-Methylpiperazino)-2-Phenyl-5-Pyrimidinecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, it should be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent moisture uptake and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.