Description

4-Chloro-6-(4-Methylphenyl)-2-Phenyl-5-Pyrimidinecarbonitrile is a high-value pyrimidine derivative, a key heterocyclic building block in advanced organic synthesis. Its precise molecular architecture makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its pyrimidine core.
• Material Science: Acts as a building block for creating organic electronic materials and liquid crystals.
• Chemical Synthesis: A versatile reagent for constructing complex heterocyclic systems in medicinal chemistry programs.
• Academic & Contract Research: Employed in university and CRO laboratories for novel methodology development and drug discovery projects.

Basic Information

Product Name	4-Chloro-6-(4-Methylphenyl)-2-Phenyl-5-Pyrimidinecarbonitrile
CAS No.	477853-91-1
Molecular Formula	C18H12ClN3
Molecular Weight	305.76 g/mol
Synonyms	4-Chloro-6-(p-tolyl)-2-phenylpyrimidine-5-carbonitrile; 2-Phenyl-4-chloro-6-(4-methylphenyl)-5-pyrimidinecarbonitrile; 5-Cyano-4-chloro-6-(4-methylphenyl)-2-phenylpyrimidine; 4-Chloro-6-(4-methylphenyl)-2-phenyl-5-cyanopyrimidine; 477853-91-1; 4-Chloro-6-(p-tolyl)-2-phenyl-5-pyrimidinecarbonitrile
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-6-(4-Methylphenyl)-2-Phenyl-5-Pyrimidinecarbonitrile adheres to strict in-process controls to ensure batch-to-batch consistency and high purity. The final product is characterized and verified using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.