Description

4-(3-Methoxyphenyl)-6-(4-Methylpiperazino)-2-Phenyl-5-Pyrimidinecarbonitrile is a high-purity, advanced pharmaceutical intermediate belonging to the pyrimidinecarbonitrile class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific kinase pathways. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted kinase inhibitors and other specialized drug candidates.
• Biochemical Research: Used as a reference standard or a starting material in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Organic Synthesis: Serves as a versatile scaffold for constructing more complex molecular architectures due to its reactive nitrile and substituted pyrimidine core.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	4-(3-Methoxyphenyl)-6-(4-Methylpiperazino)-2-Phenyl-5-Pyrimidinecarbonitrile
CAS No.	477853-89-7
Molecular Formula	C23H23N5O
Molecular Weight	385.47 g/mol
Synonyms	5-Cyano-4-(3-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine; 2-Phenyl-4-(3-methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile; 4-(3-Methoxyphenyl)-6-(4-methylpiperazin-1-yl)-2-phenylpyrimidine-5-carbonitrile; 477853-89-7; UNII-9J8U3Y4W3P; 9J8U3Y4W3P
EINECS	Contact for details

Quality Control

Our production of 4-(3-Methoxyphenyl)-6-(4-Methylpiperazino)-2-Phenyl-5-Pyrimidinecarbonitrile adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research and development. All materials are characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.