Description

2-(4-[4-(4-Methylphenyl)-2-Pyrimidinyl]Phenoxy)Acetonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrimidinyl-phenoxy acetonitrile structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals, offering a reliable building block for research and commercial-scale production. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical manufacturers, and specialty chemical companies engaged in developing novel therapeutic agents and high-value chemical products.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in kinase inhibitor research and development.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides requiring specific heterocyclic frameworks.
• Material Science Research: Serves as a precursor for organic electronic materials and liquid crystals due to its rigid, conjugated structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract manufacturing organizations (CMOs) serving the life sciences sector.

Basic Information

Item	Detail
Product Name	2-(4-[4-(4-Methylphenyl)-2-Pyrimidinyl]Phenoxy)Acetonitrile
CAS No.	477846-94-9
Molecular Formula	C19H15N3O
Molecular Weight	301.34 g/mol
Synonyms	2-[4-[4-(4-Methylphenyl)pyrimidin-2-yl]phenoxy]acetonitrile; 2-(4-(4-(p-Tolyl)pyrimidin-2-yl)phenoxy)acetonitrile; 4'-(4-Methylphenyl)-2'-pyrimidinylphenoxyacetonitrile; Acetonitrile, 2-[4-[4-(4-methylphenyl)-2-pyrimidinyl]phenoxy]-; UNII-8J5C4W3L2I; 2-(4-(4-(4-Methylphenyl)pyrimidin-2-yl)phenoxy)acetonitrile; 477846-94-9
EINECS	Contact for details

Quality Control

Our production of 2-(4-[4-(4-Methylphenyl)-2-Pyrimidinyl]Phenoxy)Acetonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity. All material is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and meet precise specifications. A Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment. Our quality system is designed to support applications requiring material traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Handle and store in accordance with good laboratory and manufacturing practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.