Description

3-(((4-Amino-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-2-Yl)Thio)Methyl)-1H-Pyrazol-5-Ol is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is valued for its role as a key synthetic building block in the development of novel therapeutic agents, particularly kinase inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry and drug discovery programs. The material is supplied with stringent quality control to ensure batch-to-batch consistency for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of targeted small-molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition mechanisms and cellular signaling pathways.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of active pharmaceutical ingredients (APIs) under development.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-(((4-Amino-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-2-Yl)Thio)Methyl)-1H-Pyrazol-5-Ol
CAS No.	477526-86-6
Molecular Formula	C₁₄H₁₄N₆OS₂
Molecular Weight	346.43 g/mol
Synonyms	4-Amino-2-(((5-hydroxy-1H-pyrazol-3-yl)methyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; 3-[[(4-Amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]methyl]-1H-pyrazol-5-ol; 477526-86-6; 3-(((4-Amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-1H-pyrazol-5-ol; Tetrahydrobenzothienopyrimidine-pyrazole derivative
EINECS	Contact for details

Quality Control

Our production of 3-(((4-Amino-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-2-Yl)Thio)Methyl)-1H-Pyrazol-5-Ol adheres to rigorous quality testing protocols to ensure it meets the exacting standards required for pharmaceutical research and development. Each batch is characterized using advanced analytical techniques, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.