Description

1-(3-(Trifluoromethoxy)Phenyl)Ethanamine is a high-value aromatic amine building block featuring a trifluoromethoxy substituent, which imparts unique physicochemical properties critical for advanced material and pharmaceutical synthesis. Its primary value lies in serving as a versatile intermediate for constructing complex molecules with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine-containing motifs into their target structures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic display technologies.
• Polymer & Resin Modifiers: Incorporated to create specialty polymers with tailored thermal and chemical resistance properties.
• Organic Synthesis & Catalysis: A valuable starting material for academic and industrial research in medicinal chemistry and catalyst ligand design.
• Fluorine Chemistry Research: Critical for studying structure-activity relationships (SAR) in drug discovery programs.

Basic Information

Product Name	1-(3-(Trifluoromethoxy)Phenyl)Ethanamine
CAS No.	477312-25-7
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	1-[3-(Trifluoromethoxy)phenyl]ethanamine; α-Methyl-3-(trifluoromethoxy)benzylamine; 1-(3-Trifluoromethoxyphenyl)ethylamine; 3-(Trifluoromethoxy)phenethylamine, N-methyl-; (RS)-1-[3-(Trifluoromethoxy)phenyl]ethanamine; m-(Trifluoromethoxy)phenethylamine; 3-(Trifluoromethoxy)-α-methylbenzylamine
EINECS	Contact for details

Quality Control

Our 1-(3-(Trifluoromethoxy)Phenyl)Ethanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements, from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and acids. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.