Description

β-Amyloid (4-10) is a specific peptide fragment derived from the amyloid precursor protein (APP). This compound is of significant research interest as a key epitope for studying the pathology and immunology of Alzheimer's disease. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on neurodegenerative disease research, diagnostics, and therapeutic development.

Application

• Biomedical Research: A critical tool for investigating the aggregation mechanisms, toxicity, and clearance pathways of amyloid-beta peptides in Alzheimer's disease models.
• Immunology Studies: Used as an antigen for the development and characterization of monoclonal and polyclonal antibodies targeting amyloid-beta.
• Diagnostic Development: Serves as a key component in the research and calibration of immunoassays (ELISA, Western Blot) and imaging agents for detecting amyloid plaques.
• Therapeutic Vaccine Research: Employed in preclinical studies for designing and evaluating active immunotherapies and vaccines aimed at mitigating amyloid plaque formation.
• Biochemical Assays: Used as a standard or reference compound in various in vitro and cell-based assays to study peptide-protein interactions and signaling pathways.
• Neuroscience Research: Fundamental for studies exploring synaptic dysfunction, neuronal inflammation, and cognitive decline associated with amyloid-beta fragments.

Basic Information

Product Name	β-Amyloid (4-10)
CAS No.	477284-32-5
Molecular Formula	C38H55N9O11
Molecular Weight	813.91 g/mol
Synonyms	Amyloid β-Protein (4-10); Aβ (4-10); β-Amyloid (4-10); Amyloid β-Peptide (4-10); H-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH; RHDSGYE; APP (672-678)
EINECS	Contact for details

Quality Control

Our β-Amyloid (4-10) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) are provided, detailing purity (by HPLC), peptide content, and results from identity confirmation tests such as Mass Spectrometry (MS).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Complies
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Complies
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.