Description

D-β-Homotryptophan-Hcl CAS NO 477250-51-4 is a high-purity, non-proteinogenic amino acid derivative, specifically the D-isomer of β-homotryptophan hydrochloride. This compound is a critical chiral building block and intermediate in advanced pharmaceutical research and development, particularly for the synthesis of novel peptide-based therapeutics and bioactive molecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-fidelity, enantiomerically pure intermediates for drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex peptide drugs and novel therapeutic agents targeting neurological and metabolic disorders.
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis to introduce modified tryptophan analogs, studying structure-activity relationships (SAR).
• Biochemical Tool Compound: Employed in enzymatic studies and as a substrate analog to investigate the specificity and mechanism of amino acid-metabolizing enzymes.
• Asymmetric Synthesis: Serves as a valuable starting material or auxiliary in asymmetric catalytic reactions to construct complex molecular architectures.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Nutraceutical & Cosmetic R&D: Investigated for potential applications in specialized nutraceutical formulations and bioactive cosmetic ingredients due to its structural similarity to essential amino acids.

Basic Information

Item	Details
Product Name	D-β-Homotryptophan Hydrochloride
CAS No.	477250-51-4
Molecular Formula	C12H15ClN2O2
Molecular Weight	254.71 g/mol
Synonyms	D-β-Homotryptophan hydrochloride; (R)-2-Amino-4-(1H-indol-3-yl)butanoic acid hydrochloride; D-2-Amino-4-(indol-3-yl)butyric acid HCl; D-BHTP-HCl; (R)-β-Homotryptophan HCl; D-4-(3-Indolyl)-2-aminobutanoic acid hydrochloride; UNII-7J3Q4I8Q3R; D-β-Homotryptophan HCl
EINECS	Contact for details

Quality Control

Our D-β-Homotryptophan-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.