Description

6-Chloromethyl-4-(4-Methoxy-Phenyl)-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring dihydropyrimidine scaffolds. It is essential for research institutions and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel dihydropyrimidinone (DHPM) based drug candidates, which exhibit a wide range of biological activities.
• API Synthesis: Used in the construction of complex molecules for potential applications in antiviral, anticancer, anti-inflammatory, and antihypertensive therapies.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals and complex organic compounds requiring the dihydropyrimidine core.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	6-Chloromethyl-4-(4-Methoxy-Phenyl)-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester
CAS No.	475042-38-7
Molecular Formula	C₁₅H₁₇ClN₂O₄
Molecular Weight	324.76 g/mol
Synonyms	Ethyl 6-(chloromethyl)-4-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate; 4-(4-Methoxyphenyl)-6-chloromethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; 6-Chloromethyl-4-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; DHPM Derivative; Biginelli Reaction Product; Dihydropyrimidinone Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. We implement strict in-process controls and final release testing, including identity confirmation, purity assessment, and impurity profiling. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for all critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.