Description

Ethyl 6-(Chloromethyl)-4-(4-Chlorophenyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS number 475042-34-3. This compound is a key synthetic building block valued for its role in constructing complex heterocyclic scaffolds essential for modern drug discovery. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

This specialized intermediate serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals. Its primary applications include:

• Pharmaceutical Intermediate: A key building block in the synthesis of dihydropyrimidinone (DHPM) derivatives, a privileged scaffold in medicinal chemistry with a wide range of biological activities.
• Drug Discovery & Development: Used in research laboratories for the design and synthesis of new chemical entities (NCEs) targeting various disease pathways.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target molecules during API development.
• Chemical Synthesis: Serves as a versatile substrate for further functionalization, enabling the creation of diverse compound libraries for screening.

Basic Information

Product Name	Ethyl 6-(Chloromethyl)-4-(4-Chlorophenyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	475042-34-3
Molecular Formula	C14H14Cl2N2O3
Molecular Weight	329.18 g/mol
Synonyms	Ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-6-chloromethyl-4-(4-chlorophenyl)-1,2,3,4-tetrahydropyrimidin-2-one; 4-(4-Chlorophenyl)-6-(chloromethyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid, 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-, ethyl ester; CAS 475042-34-3
EINECS	Contact for details

Quality Control

Our Ethyl 6-(Chloromethyl)-4-(4-Chlorophenyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.