Description

Cyclopropanamine, 1-(3,4-Difluorophenyl)- is a high-purity, fluorinated cyclopropylamine derivative, a key building block in modern organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for constructing complex molecular architectures, where the cyclopropane and difluorophenyl motifs are essential for modulating biological activity, metabolic stability, and physicochemical properties. Its precise synthesis and reliable supply are paramount for accelerating drug discovery and process development pipelines.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in CNS and psychiatric therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the difluorophenyl group enhances bioactivity and environmental stability.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis.
• Material Science: Incorporated into specialty polymers and advanced materials to impart unique chemical and physical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of target molecules.

Basic Information

Product Name	Cyclopropanamine, 1-(3,4-Difluorophenyl)-
CAS No.	474709-85-8
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	1-(3,4-Difluorophenyl)cyclopropanamine; 1-(3,4-Difluorophenyl)cyclopropylamine; 3,4-Difluoro-α-methylcyclopropylamine; (3,4-Difluorophenyl)cyclopropylamine; 1-(3,4-Difluorophenyl)cyclopropan-1-amine; α-(3,4-Difluorophenyl)cyclopropylamine; Cyclopropanamine, 1-(3,4-difluorophenyl)-; 1-Cyclopropyl-3,4-difluoroaniline
EINECS	Contact for details

Quality Control

Our Cyclopropanamine, 1-(3,4-Difluorophenyl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, GC for residual solvents, and 1H/19F NMR and IR for structural confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.