Description

Atopaxar Hydrobromide is a potent and selective antagonist of the protease-activated receptor 4 (PAR-4), a key target in platelet aggregation pathways. This high-purity active pharmaceutical ingredient (API) is critical for advanced pharmaceutical research and development, particularly in the field of novel antithrombotic and antiplatelet therapies. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation cardiovascular drugs.

Application

• Pharmaceutical R&D: Primary use as a key active pharmaceutical ingredient (API) in the development of novel antiplatelet and antithrombotic medications.
• Cardiovascular Disease Research: Critical tool for in vitro and in vivo studies targeting the PAR-4 receptor to understand and inhibit pathological platelet activation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Preclinical Studies: Used in animal models to evaluate the efficacy, pharmacokinetics, and safety profiles of potential PAR-4 antagonist drug candidates.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and functional assays to discover and characterize new compounds targeting platelet signaling.

Basic Information

Product Name	Atopaxar Hydrobromide
CAS No.	474550-69-1
Molecular Formula	C23H25FN4O3 • HBr
Molecular Weight	513.39 g/mol
Synonyms	E5555; E-5555; Atopaxar HBr; 1-(3-(Aminomethyl)phenyl)-N-(5-fluoro-2-((4-((4-methylpiperazin-1-yl)carbonyl)piperidin-1-yl)carbonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide hydrobromide; 1-[3-(Aminomethyl)phenyl]-N-[5-fluoro-2-({4-[(4-methylpiperazin-1-yl)carbonyl]piperidin-1-yl}carbonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide hydrobromide
EINECS	Contact for details

Quality Control

Our Atopaxar Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and stringent control of residual solvents and impurities to ensure it meets the exacting standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.