Description

4-Hydroxy-6-(4-Methoxyphenyl)-5-(4-Methylbenzoyl)-4-(Trifluoromethyl)Tetrahydro-2(1H)-Pyrimidinone is a high-value, structurally complex heterocyclic compound featuring a pyrimidinone core with multiple aromatic and trifluoromethyl substituents. This compound is of significant interest for its potential as a key synthetic intermediate or a pharmacologically active scaffold in advanced research and development. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in areas requiring fluorinated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorinated Compound Synthesis: The presence of the trifluoromethyl group makes it a valuable precursor for introducing fluorine into target molecules to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Research: Potential application in the development of new active ingredients for crop protection, leveraging its complex heterocyclic structure.
• Chemical Biology Probe Development: Can be utilized to create molecular probes for studying enzyme function or protein-ligand interactions in biological systems.
• Academic & Contract Research: Employed in universities and CROs (Contract Research Organizations) for fundamental organic synthesis projects and method development.

Basic Information

Product Name	4-Hydroxy-6-(4-Methoxyphenyl)-5-(4-Methylbenzoyl)-4-(Trifluoromethyl)Tetrahydro-2(1H)-Pyrimidinone
CAS No.	474302-68-6
Molecular Formula	C20H17F3N2O4
Molecular Weight	406.36 g/mol
Synonyms	4-(Trifluoromethyl)-4-hydroxy-6-(4-methoxyphenyl)-5-(4-methylbenzoyl)tetrahydro-2(1H)-pyrimidinone; 4-Hydroxy-6-(4-methoxyphenyl)-5-(4-methylbenzoyl)-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2(3H)-one; 5-(4-Methylbenzoyl)-6-(4-methoxyphenyl)-4-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrimidine-2,4-dione (tautomeric form); CAS 474302-68-6; 4-(Trifluoromethyl)dihydropyrimidine derivative.
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy-6-(4-Methoxyphenyl)-5-(4-Methylbenzoyl)-4-(Trifluoromethyl)Tetrahydro-2(1H)-Pyrimidinone is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.