Description

5-(4-Chlorobenzoyl)-4-Hydroxy-6-(Thiophen-2-Yl)-4-(Trifluoromethyl)Tetrahydropyrimidin-2(1H)-One is a high-value, structurally complex heterocyclic compound featuring a tetrahydropyrimidinone core. This molecule is of significant interest in advanced pharmaceutical research and development, particularly as a key synthetic intermediate or a potential pharmacophore. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, or inflammatory conditions.
• Agrochemical Research: Used in the development of new generation pesticides, herbicides, or fungicides, leveraging its unique heterocyclic structure for bioactivity.
• Chemical Biology Probe: Acts as a scaffold or ligand in the design of molecular probes for studying enzyme inhibition or receptor binding mechanisms.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials or ligands for catalytic systems due to the presence of multiple functional groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects requiring this precise molecular architecture.

Basic Information

Product Name	5-(4-Chlorobenzoyl)-4-Hydroxy-6-(Thiophen-2-Yl)-4-(Trifluoromethyl)Tetrahydropyrimidin-2(1H)-One
CAS No.	474008-12-3
Molecular Formula	C₁₆H₁₀ClF₃N₂O₃S
Molecular Weight	402.77 g/mol
Synonyms	4-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)-5-[(4-chlorophenyl)carbonyl]-1,4,5,6-tetrahydropyrimidin-2(1H)-one; 5-(4-Chlorobenzoyl)-4-hydroxy-6-(thiophen-2-yl)-4-(trifluoromethyl)-1,4,5,6-tetrahydropyrimidin-2(1H)-one; 4-Hydroxy-6-(thiophen-2-yl)-4-(trifluoromethyl)-5-(4-chlorobenzoyl)tetrahydropyrimidin-2(1H)-one; CAS 474008-12-3
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our advanced intermediates. Every batch of 5-(4-Chlorobenzoyl)-4-Hydroxy-6-(Thiophen-2-Yl)-4-(Trifluoromethyl)Tetrahydropyrimidin-2(1H)-One is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and physical properties are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound may be light-sensitive and/or hygroscopic; handling under an inert atmosphere is recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.