Description

Methyl 7-(Trifluoromethyl)[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylate is a high-value, heterocyclic building block characterized by its fused triazolopyrimidine core and trifluoromethyl group. This compound is essential for medicinal chemistry research and development, offering significant potential to modulate the biological activity, metabolic stability, and lipophilicity of candidate molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty chemicals and functional materials, including ligands for catalysis and organic electronic components.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards for clinical trial materials.

Basic Information

Product Name	Methyl 7-(Trifluoromethyl)[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylate
CAS No.	473994-46-6
Molecular Formula	C8H5F3N4O2
Molecular Weight	246.15 g/mol
Synonyms	Methyl 7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate; 7-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid methyl ester; Methyl 7-trifluoromethyl[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylate; 473994-46-6; [1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxylic acid, 7-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 7-(Trifluoromethyl)[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity for research and scale-up applications. All material is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We operate under a quality system designed to meet the exacting standards of the pharmaceutical and agrochemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.