Description

1-(3-o-Nosyl-5-o-Trityl-2-Deoxy--D-Lyxofuranosyl)Thymine is a sophisticated nucleoside derivative, specifically a protected thymidine analog, designed for advanced synthetic chemistry. This compound is a critical building block in the synthesis of modified oligonucleotides and nucleotide-based pharmaceuticals, offering precise control over molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostic probes, and biochemical tools.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of modified DNA/RNA strands for research and therapeutic applications (e.g., antisense oligonucleotides, aptamers).
• Biochemical Research: Used in enzymatic studies and as a substrate analog to investigate DNA polymerase mechanisms and fidelity.
• Probe Development: Integral for creating labeled nucleotides used in fluorescence in situ hybridization (FISH) and other diagnostic assays.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of nucleotide drugs.

Basic Information

Item	Detail
Product Name	1-(3-o-Nosyl-5-o-Trityl-2-Deoxy--D-Lyxofuranosyl)Thymine
CAS No.	471854-53-2
Molecular Formula	C35H31N3O8S
Molecular Weight	653.70 g/mol
Synonyms	1-[3-O-(4-Nitrobenzenesulfonyl)-5-O-triphenylmethyl-2-deoxy-β-D-lyxofuranosyl]thymine; 3'-O-Nosyl-5'-O-Trityl-thymidine; 5'-O-Trityl-3'-O-nosylthymidine; 1-(3-O-(4-Nitrobenzenesulfonyl)-5-O-trityl-2-deoxy-β-D-lyxofuranosyl)-5-methyluracil; Ns-Trt-dT; Protected Thymidine Derivative; CAS 471854-53-2
EINECS	Contact for details

Quality Control

Every batch of 1-(3-o-Nosyl-5-o-Trityl-2-Deoxy--D-Lyxofuranosyl)Thymine is manufactured and tested under strict quality management systems. We ensure compliance with high-purity standards suitable for pharmaceutical research and development. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccants and an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.