Description

{2-[3-(Trifluoromethoxy)Phenyl]Ethyl}Amine is a high-purity, fluorinated aromatic amine building block of significant interest in advanced organic synthesis. This compound matters for its unique structural motif, combining a reactive primary amine group with a trifluoromethoxy-substituted phenyl ring, which is crucial for modulating the physicochemical properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, where its fluorine-containing moiety can enhance metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group contributes to improved efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers, liquid crystals, and organic electronic materials due to its aromatic and fluorine components.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological processes and interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated aromatic amine structures.

Basic Information

Product Name	{2-[3-(Trifluoromethoxy)Phenyl]Ethyl}Amine
CAS No.	467461-10-5
Molecular Formula	C9H10F3NO
Molecular Weight	205.18 g/mol
Synonyms	2-[3-(Trifluoromethoxy)phenyl]ethan-1-amine; 3-(Trifluoromethoxy)phenethylamine; 2-(3-(Trifluoromethoxy)phenyl)ethylamine; 1-[2-Aminoethyl]-3-(trifluoromethoxy)benzene; 3-(Trifluoromethoxy)benzeneethanamine; 2-(3-Trifluoromethoxyphenyl)ethanamine; α-(3-Trifluoromethoxyphenyl)ethylamine
EINECS	Contact for details

Quality Control

Our {2-[3-(Trifluoromethoxy)Phenyl]Ethyl}Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality assurance supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.