Description

4-Chloro-3-Fluorobenzenepropanamine is a valuable fluorinated aromatic amine building block, distinguished by its unique substitution pattern. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, enabling the introduction of both chlorine and fluorine atoms to modulate biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents enhance efficacy and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of advanced polymers and liquid crystals, where the aromatic amine functionality allows for polymerization or derivatization.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags or molecular probes for biochemical and diagnostic research.
• Custom Synthesis and Contract Manufacturing: A versatile starting material for custom chemical synthesis services targeting niche applications.

Basic Information

Product Name	4-Chloro-3-Fluorobenzenepropanamine
CAS No.	465529-47-9
Molecular Formula	C9H11ClFN
Molecular Weight	187.64 g/mol
Synonyms	3-(4-Chloro-3-fluorophenyl)propan-1-amine; 4-Chloro-3-fluorobenzylpropylamine; 1-(4-Chloro-3-fluorophenyl)-3-aminopropane; 4-Chloro-3-fluoro-β-phenethylamine; Benzenepropanamine, 4-chloro-3-fluoro-; 4-Chloro-3-fluorophenethylamine (common name variant); γ-(4-Chloro-3-fluorophenyl)propylamine
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorobenzenepropanamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to air, moisture, or light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.