Description

1-[4-(Trifluoromethyl)-2-Pyrimidinyl]-4-Piperidinecarboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylpyrimidine-piperidine scaffold. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Critical intermediate in the research and development of novel kinase inhibitors for oncology.
• Key building block for the synthesis of potential CNS-targeting drug candidates.
• Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Essential raw material in custom synthesis and contract manufacturing of high-value APIs.
• Employed in academic and industrial research exploring trifluoromethyl-substituted heterocycles.
• Precursor for labeled compounds used in pharmacokinetic and metabolic studies (e.g., deuterated or C14-labeled analogs).

Basic Information

Product Name	1-[4-(Trifluoromethyl)-2-Pyrimidinyl]-4-Piperidinecarboxamide
CAS No.	465514-29-8
Molecular Formula	C11H13F3N4O
Molecular Weight	274.25 g/mol
Synonyms	4-Piperidinecarboxamide, 1-[4-(trifluoromethyl)-2-pyrimidinyl]-; 1-(4-(Trifluoromethyl)pyrimidin-2-yl)piperidine-4-carboxamide; 465514-29-8; UNII-6Q4H6J2W3I; 6Q4H6J2W3I; CHEMBL3186667; BDBM50111047; AKOS015915923; AS-10233; FT-0658081
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)-2-Pyrimidinyl]-4-Piperidinecarboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.