Description

Rapacuroniumbromide CAS NO 465499-11-0 is a non-depolarizing neuromuscular blocking agent (NMBA) belonging to the aminosteroid class, primarily used as a skeletal muscle relaxant in clinical anesthesia. Its value lies in providing rapid onset and short duration of action, facilitating rapid sequence intubation and controlled muscle relaxation during surgical procedures. This high-purity pharmaceutical intermediate is essential for manufacturers in the pharmaceutical and fine chemical sectors engaged in the synthesis of advanced anesthetic agents and research into neuromuscular pharmacology.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of injectable neuromuscular blocking agents for general anesthesia.
• Clinical Anesthesia: Used to induce skeletal muscle relaxation during surgical procedures, enabling optimal operating conditions.
• Rapid Sequence Intubation (RSI): Facilitates quick and secure airway management in emergency and critical care settings due to its fast onset.
• Pharmacological Research: Serves as a reference standard and key intermediate in studies exploring neuromuscular transmission and new anesthetic compounds.
• Fine Chemical Synthesis: A critical building block for the chemical synthesis of more complex steroidal neuromuscular agents and derivatives.
• GMP Manufacturing: Supplied as a high-purity intermediate for use in Good Manufacturing Practice (GMP) compliant production lines for final dosage forms.

Basic Information

Product Name	Rapacuroniumbromide
CAS No.	465499-11-0
Molecular Formula	C32H53BrN2O4
Molecular Weight	609.69 g/mol
Synonyms	Rapacuronium Bromide; Org 9487; (3α,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl 1-(2-propenyl)pyrrolidinium Bromide; 16β-[1-(Allyl)pyrrolidinio]-3α,17β-diacetoxy-2β-piperidino-5α-androstane Bromide; 2β,16β-Bis(1-pyrrolidinyl)-3α,17β-diacetoxy-5α-androstane Bromide Allyl Derivative; Rapacuronium
EINECS	Contact for details

Quality Control

Our Rapacuroniumbromide is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, and is supported by a detailed Certificate of Analysis (COA). We adhere to relevant ICH guidelines and can supply material suitable for use in GMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.