Description

tert-Butyl 3-(4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Azetane-1-Carboxylate is a high-purity, heterocyclic organic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate, enabling the construction of complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents, particularly kinase inhibitors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small molecule drugs, especially in oncology research.
• Kinase Inhibitor Development: Core scaffold for the research and development of potent and selective protein kinase inhibitors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up and manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in the development of chemical probes for studying cellular signaling pathways.
• Custom Synthesis: Building block for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	tert-Butyl 3-(4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Azetane-1-Carboxylate
CAS No.	461699-22-9
Molecular Formula	C13H17IN6O2
Molecular Weight	416.22 g/mol
Synonyms	1-(1-(tert-Butoxycarbonyl)azetidin-3-yl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-[1-[(1,1-dimethylethoxy)carbonyl]-3-azetidinyl]-3-iodo-; tert-Butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)azetidine-1-carboxylate; 3-Iodo-1-(1-(tert-butoxycarbonyl)azetidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; BOC-protected 3-iodo PP1 azetidine derivative; Azetidine-1-carboxylic acid, 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(4-Amino-3-Iodo-1H-Pyrazolo[3,4-D]Pyrimidin-1-Yl)Azetane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure the material meets the stringent requirements for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.