Description

N-(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homoserine is a protected derivative of the non-proteinogenic amino acid D-homoserine, featuring the acid-labile Fmoc (9-fluorenylmethoxycarbonyl) protecting group. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry and side-chain functionality. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, solid-phase peptide synthesis (SPPS), and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid derivative for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research & Development: Serves as a chiral intermediate in the synthesis of peptide-based drug candidates, including enzyme inhibitors and receptor agonists/antagonists.
• Bioconjugation & Chemical Biology: Used to incorporate the D-homoserine moiety with a protected side chain into proteins or other biomolecules for structure-activity relationship (SAR) studies.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Synthesis of Non-Natural Amino Acids: Acts as a precursor for further chemical modification to create novel, tailor-made amino acid analogs.

Basic Information

Product Name	N-(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homoserine
CAS No.	461692-98-8
Molecular Formula	C20H19NO5
Molecular Weight	353.37 g/mol
Synonyms	Fmoc-D-homoserine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-hydroxybutanoic acid; D-Homoserine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homoserine; Fmoc-D-Hse-OH; Fmoc-D-homoSer-OH; N-Fmoc-D-homoserine; (R)-4-Hydroxy-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid
EINECS	Contact for details

Quality Control

Our N-(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homoserine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral HPLC data, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.