Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl L-Trp(2-Me)-Oh is a specialized, protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in enabling the precise and efficient construction of complex peptides and peptidomimetics, particularly those containing tryptophan analogs. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for developing novel therapeutic peptides, diagnostic agents, and biochemical tools, ensuring high coupling efficiency and minimal side reactions during synthesis.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of modified tryptophan residues into peptide chains.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide tags and linkers used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Peptidomimetic Design: Essential for synthesizing non-natural peptide analogs with enhanced stability, bioavailability, or target specificity.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive compounds.
• Biochemical Tool Development: Used to create labeled or modified peptides for proteomics research and mechanistic studies.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl L-Trp(2-Me)-Oh
CAS No.	460751-70-6
Molecular Formula	C27H24N2O4
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-L-Trp(2-Me)-OH; Fmoc-2-Methyl-L-tryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-tryptophan; (2S)-3-(1H-Indol-3-yl)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-methylpropanoic Acid; Fmoc-2-Me-Trp-OH; Nα-Fmoc-2-methyl-L-tryptophan; Fmoc-2-methyltryptophan; Fmoc-Trp(2Me)-OH
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl L-Trp(2-Me)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.