Description

n-Fmoc-5-Methoxy-L-Tryptophan is a protected derivative of the essential amino acid L-tryptophan, featuring both an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amine and a methoxy substituent on the indole ring. This compound is critically important as a high-purity building block for solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of modified tryptophan residues into complex peptide sequences. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid for the automated synthesis of peptides containing methoxy-tryptophan modifications.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based drugs, hormones, and diagnostic agents where tryptophan analogs can influence bioactivity and stability.
• Bioconjugation & Probe Development: Acts as a precursor for creating fluorescent or affinity-labeled peptides due to the reactive indole moiety of the tryptophan side chain.
• Academic & Biochemical Research: Employed in studies investigating protein-protein interactions, enzyme substrates, and the structure-activity relationships of peptides.
• Production of Custom Peptides: Essential raw material for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide synthesis services.

Basic Information

Product Name	n-Fmoc-5-Methoxy-L-Tryptophan
CAS No.	460751-69-3
Molecular Formula	C₂₈H₂₆N₂O₅
Molecular Weight	470.52 g/mol
Synonyms	Fmoc-5-MeO-L-Trp-OH; Fmoc-5-Methoxy-L-tryptophan; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-methoxy-L-tryptophan; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[5-methoxy-1H-indol-3-yl]propanoic acid; 5-Methoxy-L-tryptophan, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-Fmoc-5-methoxy-L-tryptophan; Fmoc-5-methoxy-Trp-OH; Fmoc-Trp(5-OMe)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-5-Methoxy-L-Tryptophan is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.