Description

6-Amino-2-{[(2-Chloro-6-Fluorophenyl)Methyl]Sulfanyl}-3,4-Dihydropyrimidin-4-One is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, or oncology.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) due to its reactive amino and sulfanyl groups.
• Agrochemical Research: Serves as a potential intermediate in the development of new herbicides or fungicides, leveraging its dihydropyrimidinone core.
• Academic & Industrial R&D: Employed in research laboratories for methodological studies in heterocyclic chemistry and as a reference standard.

Basic Information

Product Name	6-Amino-2-{[(2-Chloro-6-Fluorophenyl)Methyl]Sulfanyl}-3,4-Dihydropyrimidin-4-One
CAS No.	459178-69-9
Molecular Formula	C11H9ClFN3OS
Molecular Weight	285.72 g/mol
Synonyms	6-Amino-2-[(2-chloro-6-fluorobenzyl)thio]-3,4-dihydropyrimidin-4(3H)-one; 2-((2-Chloro-6-fluorobenzyl)thio)-6-amino-3,4-dihydropyrimidin-4(3H)-one; 4(3H)-Pyrimidinone, 6-amino-2-[[(2-chloro-6-fluorophenyl)methyl]thio]-3,4-dihydro-; 6-Amino-2-((2-chloro-6-fluorobenzyl)thio)-3,4-dihydropyrimidin-4(3H)-one; CAS 459178-69-9
EINECS	Contact for details

Quality Control

Our production of 6-Amino-2-{[(2-Chloro-6-Fluorophenyl)Methyl]Sulfanyl}-3,4-Dihydropyrimidin-4-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.