Description

2,5-Dichloro-L-Phenylalanine Hydrochloride is a high-purity, non-natural amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecules with precise stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery, process development, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified phenylalanine residues, altering peptide stability and bioactivity.
• Agrochemical Research: Serves as a building block for developing new chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study enzyme mechanisms and protein-protein interactions.
• Ligand Development: Utilized in creating specialized ligands for asymmetric catalysis and metal complexation.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	2,5-Dichloro-L-Phenylalanine Hydrochloride
CAS No.	457654-89-6
Molecular Formula	C9H10Cl2NO2 • HCl
Molecular Weight	280.55 g/mol (Free base: 244.09 g/mol)
Synonyms	(2S)-2-Amino-3-(2,5-dichlorophenyl)propanoic acid hydrochloride; L-2,5-Dichlorophenylalanine HCl; 2,5-Dichloro-DL-phenylalanine hydrochloride (related); 2,5-DCPhe-OH • HCl; (S)-2-Amino-3-(2,5-dichlorophenyl)propionic acid hydrochloride; 2,5-Dichloro-L-Phe HCl; 2,5-Dichloro-L-α-aminohydrocinnamic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-L-Phenylalanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.