Description

L-Norvaline, n-[(1,1-Dimethylethoxy)Carbonyl]-5,5,5-Trifluoro- CAS NO 453556-65-5 is a protected, fluorinated derivative of the non-proteinogenic amino acid L-norvaline, featuring a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical building block in advanced organic synthesis, offering a unique trifluoromethyl group that can significantly alter the physicochemical properties of target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel peptides, peptidomimetics, and bioactive compounds where enhanced metabolic stability, lipophilicity, or specific steric profiles are desired.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a fluorinated norvaline residue, enabling structure-activity relationship (SAR) studies.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, or plant growth regulators that leverage the properties of fluorine.
• Chemical Biology Probes: Employed in the design and synthesis of labeled peptides or inhibitors for studying enzyme mechanisms and protein interactions.
• Material Science: Potential monomer or modifier for creating specialty polymers with unique surface characteristics or stability.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for complex molecules in pilot plant and commercial manufacturing.

Basic Information

Product Name	L-Norvaline, n-[(1,1-Dimethylethoxy)Carbonyl]-5,5,5-Trifluoro-
CAS No.	453556-65-5
Molecular Formula	C₁₀H₁₆F₃NO₄
Molecular Weight	271.23 g/mol
Synonyms	Boc-5,5,5-Trifluoro-L-norvaline; (S)-2-((tert-Butoxycarbonyl)amino)-5,5,5-trifluoropentanoic acid; N-Boc-5,5,5-trifluoro-L-norvaline; N-(tert-Butoxycarbonyl)-5,5,5-trifluoro-L-norvaline; Boc-TrifluoroLnorvaline-OH; 5,5,5-Trifluoro-L-norvaline N-Boc derivative; N-Boc-5,5,5-trifluoronorvaline
EINECS	Contact for details

Quality Control

Our L-Norvaline, n-[(1,1-Dimethylethoxy)Carbonyl]-5,5,5-Trifluoro- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are provided with every shipment. We can support development projects requiring compliance with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers should be kept sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.