Description

5-Pyrimidinecarboxylicacid,1,2,3,4-Tetrahydro-6-Methyl-2-Oxo-4-(Trichloromethyl)-,Methylester(9Ci) CAS NO 452357-78-7 is a specialized heterocyclic building block featuring a pyrimidine core with a trichloromethyl substituent. This compound is valued for its unique molecular architecture, which makes it a critical intermediate in advanced organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing antiviral properties.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, or insecticides, leveraging the reactivity of the trichloromethyl group.
• Chemical Synthesis Building Block: Employed in organic chemistry research to construct complex heterocyclic frameworks for material science and catalysis studies.
• Active Pharmaceutical Ingredient (API) Development: Functions as a core structural motif during the early-stage discovery and process chemistry phases for new APIs.
• Biochemical Probe Synthesis: Utilized to create labeled or modified compounds for biochemical and pharmacological research applications.

Basic Information

Product Name	5-Pyrimidinecarboxylicacid,1,2,3,4-Tetrahydro-6-Methyl-2-Oxo-4-(Trichloromethyl)-,Methylester(9Ci)
CAS No.	452357-78-7
Molecular Formula	C₈H₉Cl₃N₂O₃
Molecular Weight	287.52 g/mol
Synonyms	Methyl 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(trichloromethyl)pyrimidine-5-carboxylate; 4-(Trichloromethyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylic acid methyl ester; 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(trichloromethyl)-, methyl ester; Methyl 4-(trichloromethyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate; 452357-78-7; Trichloromethyl-substituted dihydropyrimidine ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Quality is verified through analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. The compound may be moisture-sensitive; handle and store under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.