Description

6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)Pyrido[2,3-D]Pyrimidin-7(8H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly kinase inhibitors. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of targeted cancer therapies and other specialized medicinal compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary kinase inhibitor drugs for oncology research and development.
• Biochemical Research: Used as a reference standard or a scaffold molecule in high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Development: Serves as a potential intermediate for creating novel crop protection agents due to its complex heterocyclic structure.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Item	Details
Product Name	6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)Pyrido[2,3-D]Pyrimidin-7(8H)-One
CAS No.	449811-12-5
Molecular Formula	C₁₆H₁₁F₂N₃O₂S
Molecular Weight	347.34 g/mol
Synonyms	8-Methyl-2-(methylthio)-6-(2,4-difluorophenoxy)pyrido[2,3-d]pyrimidin-7(8H)-one; 6-(2,4-Difluorophenoxy)-8-methyl-2-(methylsulfanyl)pyrido[2,3-d]pyrimidin-7-one; 449811-12-5; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,4-difluorophenoxy)-8-methyl-2-(methylthio)-; 2-(Methylthio)-6-(2,4-difluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
EINECS	Contact for details

Quality Control

Our production of 6-(2,4-Difluorophenoxy)-8-Methyl-2-(Methylthio)Pyrido[2,3-D]Pyrimidin-7(8H)-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research and development grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.