Description

Proline, 3-(1-Methylethyl)- (9Ci) is a specialized proline derivative, a non-proteinogenic amino acid analog with a branched isopropyl side chain at the 3-position. This structural modification imparts unique steric and lipophilic properties, making it a valuable chiral building block and scaffold in advanced organic synthesis. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for applications in medicinal chemistry, peptide mimetics, and as a precursor for chiral catalysts and ligands.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for introducing conformational constraints in peptide-based drugs.
• Peptidomimetics & Drug Design: Used to synthesize modified peptides and peptidomimetics to enhance metabolic stability, bioavailability, and target selectivity.
• Agrochemical Research: Employed as a building block in the synthesis of chiral herbicides, fungicides, and plant growth regulators.
• Chiral Catalyst & Ligand Synthesis: Acts as a precursor for the development of asymmetric catalysts and ligands used in enantioselective synthesis.
• Biochemical Research: Utilized in studies of enzyme inhibition, receptor binding, and as a probe for investigating biological systems.
• Fine Chemical Synthesis: Applied in the custom synthesis of complex, high-value organic molecules for various industrial research applications.

Basic Information

Product Name	Proline, 3-(1-Methylethyl)- (9Ci)
CAS No.	449758-66-1
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	3-Isopropylproline; 3-(1-Methylethyl)proline; 3-Isopropyl-L-proline (if L-form); 3-Isopropyl-DL-proline; 3-(Propan-2-yl)pyrrolidine-2-carboxylic acid; 3-Isopropyl-2-carboxypyrrolidine; (3-Isopropylpyrrolidin-2-yl)carboxylic acid
EINECS	Contact for details

Quality Control

Our Proline, 3-(1-Methylethyl)- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and chiral purity analysis to ensure identity, potency, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.