Description

Furo[2,3-D]Pyrimidine-6-Carboxylic Acid, 1,2,3,4-Tetrahydro-1-Methyl-2,4-Dioxo-3-(Phenylmethyl)-, Benzo[B]Thien-6-Ylmethyl Ester is a high-purity, complex heterocyclic organic compound with the CAS number 448969-70-8. This advanced pharmaceutical intermediate is critical for research and development in medicinal chemistry, particularly for its role as a key building block in synthesizing novel therapeutic agents. It is primarily sought by R&D laboratories, pharmaceutical manufacturers, and CROs (Contract Research Organizations) engaged in developing new drug candidates, especially within oncology and targeted therapy programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Kinase Inhibitor Development: Its fused furopyrimidine-thiophene structure makes it valuable for research into protein kinase inhibitors, a major class of oncology drugs.
• Chemical Biology Probes: Employed in the design and synthesis of chemical probes to study specific biological pathways and target validation.
• Process Chemistry & Scale-Up: Used in route scouting and process optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in organic synthesis and drug discovery.

Basic Information

Product Name	Furo[2,3-D]Pyrimidine-6-Carboxylic Acid, 1,2,3,4-Tetrahydro-1-Methyl-2,4-Dioxo-3-(Phenylmethyl)-, Benzo[B]Thien-6-Ylmethyl Ester
CAS No.	448969-70-8
Molecular Formula	C24H20N2O5S
Molecular Weight	448.49 g/mol
Synonyms	Benzo[b]thien-6-ylmethyl 1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(phenylmethyl)furo[2,3-d]pyrimidine-6-carboxylate; 3-Benzyl-1-methyl-2,4-dioxo-1,2,3,4-tetrahydrofuro[2,3-d]pyrimidine-6-carboxylic acid benzothiophen-6-ylmethyl ester; Furo[2,3-d]pyrimidine-6-carboxylic acid, 1,2,3,4-tetrahydro-1-methyl-2,4-dioxo-3-(phenylmethyl)-, 6-benzothienylmethyl ester; 448969-70-8; Benzothiophene-substituted furopyrimidine derivative.
EINECS	Contact for details

Quality Control

Our Furo[2,3-D]Pyrimidine-6-Carboxylic Acid Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.