Description

L-Pyrrolysine is a rare, naturally occurring, genetically encodable amino acid that expands the genetic code beyond the standard 20 amino acids. This compound is of significant interest in biochemical research and synthetic biology for its role in creating novel proteins with unique functions. It is primarily utilized by researchers and developers in the fields of biotechnology, pharmaceutical development, and advanced materials science to engineer enzymes and therapeutics with enhanced properties.

Application

• Genetic Code Expansion Research: Used as a tool for incorporating non-canonical amino acids into recombinant proteins in response to the amber stop codon.
• Enzyme Engineering: Facilitates the creation of novel biocatalysts with tailored activity, stability, or substrate specificity for industrial processes.
• Therapeutic Protein Development: Enables the site-specific introduction of unique chemical handles or functional groups into antibodies, peptides, and other biologics.
• Basic Biochemical Studies: Serves as a critical reagent for studying the structure, function, and biosynthesis of pyrrolysine-containing proteins in methanogenic archaea.
• Synthetic Biology Platforms: A key component in developing orthogonal translation systems for programming new biological functions.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in molecular biology and chemical biology.

Basic Information

Product Name	L-Pyrrolysine
CAS No.	448235-52-7
Molecular Formula	C₁₂H₂₁N₃O₃
Molecular Weight	255.31 g/mol
Synonyms	(2R)-2-Amino-3-{[(2R,3R)-3-methyl-4-{(3R)-3-methyl-1,2,3,4-tetrahydro-2H-pyrrol-3-yl}-L-lysine; Pyl; (S)-2-Amino-6-{[(2R,3R)-3-methyl-4-{(3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl}butanoyl]amino}hexanoic acid; N⁶-{[(2R,3R)-3-methyl-4-{(3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl}butanoyl]}-L-lysine; 22nd Amino Acid
EINECS	Contact for details

Quality Control

Our L-Pyrrolysine is produced and handled under strict quality management protocols to ensure the high purity and consistency required for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the manufacturing of advanced biochemical intermediates, ensuring traceability and reliability for our global clientele in academia and industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider keeping the container under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Functional in in vitro translation assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.