Description

1-(4-Acetylphenyl)-2,4-Dioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrimidinecarbonitrile core structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and serves as a versatile building block in medicinal chemistry research. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting kinase inhibition and other enzymatic pathways.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the multi-step synthesis of novel APIs for preclinical and clinical development.
• Biochemical Reagent: Employed in biochemical assays and as a reference standard for analytical method development and validation.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for specialized, high-value chemical products.

Basic Information

Product Name	1-(4-Acetylphenyl)-2,4-Dioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarbonitrile
CAS No.	446276-09-1
Molecular Formula	C13H9N3O3
Molecular Weight	255.23 g/mol
Synonyms	5-Cyano-1-(4-acetylphenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-Acetylphenyl)-5-cyanodihydropyrimidine-2,4(1H,3H)-dione; 1-(4-Acetylphenyl)dihydro-5-pyrimidinecarbonitrile-2,4(1H,3H)-dione; 5-Cyano-1-[4-(acetyl)phenyl]pyrimidine-2,4(1H,3H)-dione; 446276-09-1; 1-(4-Acetylphenyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-(4-Acetylphenyl)-2,4-Dioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.