Description

3-(Difluoromethyl)-4-Fluoroaniline Hydrochloride is a high-purity, halogenated aniline derivative offered as a stable hydrochloride salt. This compound serves as a critical pharmaceutical intermediate and agrochemical building block, valued for its fluorine-containing motifs which are essential for modulating the biological activity and metabolic stability of target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical and crop protection industries for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the difluoromethyl and fluoro groups enhance efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and advanced materials requiring fluorine incorporation.
• Organic Synthesis: A versatile reagent for introducing the 3-(difluoromethyl)-4-fluoroaniline moiety into more complex molecular architectures via coupling reactions.
• Chemical Reference Standard: Used in analytical laboratories for method development and quality control of related substances.

Basic Information

Product Name	3-(Difluoromethyl)-4-Fluoroaniline Hydrochloride
CAS No.	445303-28-6
Molecular Formula	C7H7ClF3N
Molecular Weight	197.59 g/mol
Synonyms	4-Fluoro-3-(difluoromethyl)aniline hydrochloride; 3-(Difluoromethyl)-4-fluoro-benzenamine hydrochloride; 4-Fluoro-α,α-difluoro-m-toluidine hydrochloride; 1-Amino-2-fluoro-5-(difluoromethyl)benzene hydrochloride; Benzenamine, 4-fluoro-3-(difluoromethyl)-, hydrochloride (1:1); 4-Fluoro-3-difluoromethylphenylamine HCl
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)-4-Fluoroaniline Hydrochloride is manufactured under a cGMP-compliant quality management system, ensuring batch-to-batch consistency and traceability. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.