Description

Isopropyl 7-(Difluoromethyl)-5-(4-Methylphenyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its precise molecular architecture, which serves as a critical building block in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and antiviral research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of targeted small-molecule drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• API Synthesis: Integral building block in multi-step synthetic routes for complex active pharmaceutical ingredients.
• Biochemical Research: Employed as a tool compound in biochemical assays and target validation studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic and pharmacological studies.

Basic Information

Product Name	Isopropyl 7-(Difluoromethyl)-5-(4-Methylphenyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate
CAS No.	445230-67-1
Molecular Formula	C18H17F2N3O2
Molecular Weight	345.35 g/mol
Synonyms	7-(Difluoromethyl)-5-(4-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid isopropyl ester; Isopropyl 7-(difluoromethyl)-5-p-tolylpyrazolo[1,5-a]pyrimidine-3-carboxylate; 445230-67-1; Pyrazolo[1,5-a]pyrimidine-3-carboxylate derivative; DFMPP-IPA; 5-(4-Methylphenyl)-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic Acid Isopropyl Ester
EINECS	Contact for details

Quality Control

Our Isopropyl 7-(Difluoromethyl)-5-(4-Methylphenyl)Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all critical quality attributes. We support development and commercial projects with material suitable for research use and can supply material produced under cGMP guidelines for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.