Description

4-(Aminomethyl)-3-Fluorophenol Hydrochloride is a specialized fluorinated aromatic building block with a phenol and a primary amine hydrochloride functional group. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chelating ligands or organocatalysts used in asymmetric synthesis and metal-catalyzed reactions.
• Fluorescent Probe and Dye Chemistry: The phenolic and amine groups allow for conjugation, making it useful in developing fluorescent markers and specialty dyes for biochemical applications.
• Material Science Research: Employed in the synthesis of advanced polymers or functional materials where fluorinated aromatic units impart specific chemical resistance or physical properties.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise, high-purity fluorinated intermediates.

Basic Information

Product Name	4-(Aminomethyl)-3-Fluorophenol Hydrochloride
CAS No.	444807-63-0
Molecular Formula	C7H9ClFNO
Molecular Weight	177.60 g/mol
Synonyms	3-Fluoro-4-(aminomethyl)phenol hydrochloride; 4-(Aminomethyl)-3-fluorophenol HCl; 1-Fluoro-2-hydroxy-5-(aminomethyl)benzene hydrochloride; (3-Fluoro-4-hydroxyphenyl)methanamine hydrochloride; Benzenemethanamine, 3-fluoro-4-hydroxy-, hydrochloride; 3-Fluoro-4-hydroxybenzylamine hydrochloride; 4-Hydroxy-3-fluorobenzylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Aminomethyl)-3-Fluorophenol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.