Description

n-(2-Chloropyrimidin-4-Yl)-N,2,3-Trimethyl-2H-Indazol-6-Amine is a high-purity, advanced pharmaceutical intermediate featuring a fused indazole-pyrimidine core structure. This compound is of significant value for medicinal chemistry research and development, serving as a key building block in the synthesis of targeted therapeutic agents. It is primarily utilized by R&D teams and process chemists in the pharmaceutical and biotechnology industries for the development of novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of small molecule drugs targeting various disease pathways.
• Kinase Inhibitor Development: Used in research for creating potent and selective kinase inhibitors due to its privileged heterocyclic scaffold.
• Medicinal Chemistry & SAR Studies: Serves as a core structure for structure-activity relationship (SAR) optimization to improve drug efficacy and safety profiles.
• Pre-clinical Research Compound: Employed in the discovery and early development stages of new chemical entities (NCEs).
• Chemical Biology Probes: Utilized to develop tool compounds for studying specific biological targets and mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-(2-Chloropyrimidin-4-Yl)-N,2,3-Trimethyl-2H-Indazol-6-Amine
CAS No.	444731-75-3
Molecular Formula	C₁₄H₁₅ClN₆
Molecular Weight	302.76 g/mol
Synonyms	N-(2-Chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine; 6-[(2-Chloro-4-pyrimidinyl)amino]-2,3-dimethyl-2H-indazole; 444731-75-3; UNII-8K8K4Q9V8I; 8K8K4Q9V8I; N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine; BDBM50389373; AKOS025310647.
EINECS	Contact for details

Quality Control

Our n-(2-Chloropyrimidin-4-Yl)-N,2,3-Trimethyl-2H-Indazol-6-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.