Description

n-(2-Chloropyrimidin-4-Yl)-2,3-Dimethyl-2H-Indazol-6-Amine CAS NO 444731-74-2 is a high-purity, heterocyclic organic compound featuring a chloropyrimidine core linked to a dimethylindazole moiety. This specific molecular architecture makes it a critical building block (advanced intermediate) for pharmaceutical research and development, particularly in the synthesis of kinase inhibitors and other targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing novel drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of small-molecule drugs, especially kinase inhibitors for oncology and inflammatory diseases.
• Biochemical Research: Used as a reference standard or a probe compound in enzymatic assays and target validation studies.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis: Employed in the contract manufacturing of complex Active Pharmaceutical Ingredients (APIs) and novel chemical entities (NCEs).
• Chemical Biology: Can be utilized for the synthesis of chemical probes to study specific biological pathways and protein functions.

Basic Information

Product Name	n-(2-Chloropyrimidin-4-Yl)-2,3-Dimethyl-2H-Indazol-6-Amine
CAS No.	444731-74-2
Molecular Formula	C13H12ClN5
Molecular Weight	273.72 g/mol
Synonyms	2,3-Dimethyl-2H-indazol-6-amine, N-(2-chloro-4-pyrimidinyl)-; 6-[(2-Chloropyrimidin-4-yl)amino]-2,3-dimethyl-2H-indazole; 2,3-Dimethyl-N-(2-chloropyrimidin-4-yl)-2H-indazol-6-amine; 444731-74-2; N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine; 2H-Indazol-6-amine, 2,3-dimethyl-N-(2-chloro-4-pyrimidinyl)-
EINECS	Contact for details

Quality Control

Our production of n-(2-Chloropyrimidin-4-Yl)-2,3-Dimethyl-2H-Indazol-6-Amine adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure consistent quality and traceability. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.