Description

Clopidogrel is a potent antiplatelet agent belonging to the thienopyridine class of pharmaceuticals. Its primary value lies in its ability to selectively and irreversibly inhibit platelet aggregation, making it a cornerstone in the prevention of atherothrombotic events. This high-purity active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry developing generic and proprietary cardiovascular medications. It is supplied as Clopidogrel CAS NO 444728-15-8, meeting the stringent quality standards required for pharmaceutical synthesis.

Application

Clopidogrel is a critical component in the formulation of life-saving cardiovascular drugs. Its primary and derived applications include:

• Active Pharmaceutical Ingredient (API): Core component in the manufacture of antiplatelet tablets, most commonly as clopidogrel bisulfate (hydrogen sulfate).
• Cardiovascular Disease Prevention: Used in medications to prevent blood clots in patients with a history of recent heart attack, stroke, or established peripheral arterial disease.
• Acute Coronary Syndrome Management: Formulated into drugs used in conjunction with aspirin for patients undergoing percutaneous coronary intervention (PCI) such as stent placement.
• Generic Drug Production: Serves as the key raw material for manufacturers producing bioequivalent versions of originator antiplatelet drugs.
• Pharmaceutical Research & Development: Utilized in preclinical and clinical studies for developing new combination therapies or novel drug delivery systems for antiplatelet treatment.
• Dosage Form Development: Employed in the R&D of various solid oral dosage forms, including standard and controlled-release formulations.

Basic Information

Product Name	Clopidogrel
CAS No.	444728-15-8
Molecular Formula	C16H16ClNO2S
Molecular Weight	321.82 g/mol
Synonyms	Clopidogrel Base; (S)-(+)-Clopidogrel; Methyl (S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate; SR 25989C; PCR 4099; Plavix API (referring to the base compound); Dextro-Clopidogrel; (S)-Clopidogrel
EINECS	Contact for details

Quality Control

Our Clopidogrel is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets or exceeds relevant pharmacopeial standards for pharmaceutical intermediates/APIs, including identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay, enantiomeric purity, and specified impurities. We are committed to cGMP compliance to ensure consistent quality and traceability for our global pharmaceutical clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.5% (S-isomer)
Related Substances (HPLC)	Individual unspecified impurity: ≤ 0.10% Total impurities: ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.