Description

7-[3,5-Bis-o-[(2,4-Dichlorophenyl)Methyl]-2-C-Methyl-β-D-Ribofuranosyl]-4-Chloro-5-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate with a complex nucleoside analog structure. This compound is critical for research and development in novel antiviral and anticancer therapeutic agents, offering a key building block for targeted drug discovery. It is primarily needed by pharmaceutical R&D laboratories, biotechnology firms, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the synthesis of next-generation nucleoside-based pharmaceuticals.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel antiviral and anticancer drugs.
• Biochemical Research: Used as a reference standard and probe in enzymatic studies and mechanism-of-action research for nucleoside analogs.
• Antiviral Drug Development: A critical scaffold for the synthesis of experimental compounds targeting viral polymerases and reverse transcriptases.
• Oncology Research: Investigated for its potential incorporation into chemotherapeutic agents designed to disrupt DNA/RNA synthesis in cancer cells.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) of modified nucleosides.

Basic Information

Item	Detail
Product Name	7-[3,5-Bis-o-[(2,4-Dichlorophenyl)Methyl]-2-C-Methyl-β-D-Ribofuranosyl]-4-Chloro-5-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	443642-54-4
Molecular Formula	C27H25Cl3N4O4
Molecular Weight	575.87 g/mol
Synonyms	4-Chloro-7-[3,5-bis-O-[(2,4-dichlorophenyl)methyl]-2-C-methyl-β-D-ribofuranosyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine; 7-[3,5-Bis-O-[(2,4-dichlorobenzyl)]-2-C-methyl-β-D-ribofuranosyl]-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine; 443642-54-4; 7H-Pyrrolo[2,3-d]pyrimidine nucleoside derivative; Dichlorobenzyl-protected nucleoside analog; Advanced nucleoside intermediate
EINECS	Contact for details

Quality Control

Our 7-[3,5-Bis-o-[(2,4-Dichlorophenyl)Methyl]-2-C-Methyl-β-D-Ribofuranosyl]-4-Chloro-5-Methyl-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere if specified. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.