Description

Benzenamine, 3-(Fluoroethynyl)- (9Ci) is a specialized fluorinated aniline derivative, identified by CAS number 443129-73-5. This compound serves as a high-value building block in advanced organic synthesis, prized for its unique combination of an amine handle and a fluoroalkyne moiety. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical sectors to introduce fluorine atoms into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and advanced materials with tailored surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the electron-withdrawing fluoroethynyl group.
• Fluorine-18 Radiochemistry: A potential precursor for the synthesis of positron emission tomography (PET) imaging agents, given its fluoroalkyne structure.
• Life Sciences Reagent: Used as a biochemical probe or a labeling reagent in proteomics and chemical biology research.

Basic Information

Item	Details
Product Name	Benzenamine, 3-(Fluoroethynyl)- (9Ci)
CAS No.	443129-73-5
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	3-(Fluoroethynyl)aniline; 3-Ethynyl-4-fluoroaniline; 4-Fluoro-3-ethynylaniline; 3-Amino-1-fluoro-4-ethynylbenzene; m-(Fluoroethynyl)aniline; 1-Fluoro-3-amino-4-ethynylbenzene; 3-(1-Fluoroethynyl)benzenamine
EINECS	Contact for details

Quality Control

Every batch of Benzenamine, 3-(Fluoroethynyl)- is produced under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic route. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider using an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Light yellow to brown solid or liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.